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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T63514 | PPARγ agonist 1 | ||
PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects. pparγ agonist 1 has shown research potential in cardiovascular diseases assoc... | |||
T60184 | TUG-499 | GPR , PPAR | |
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA2, FFA3 and the nuclear receptor PPARγ, as well as other di... | |||
T6524 | GW0742 | GW610742 | PPAR |
GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ). | |||
T61731 | PPARγ agonist 4 | ||
PPARγ agonist 4 (Compound 18b), a potent and selective PPARγ agonist, demonstrates antitumor efficacy only when used in conjunction with Imatinib. Notably, PPARγ agonist 4 does not exhibit cytotoxic effects on either non... | |||
T61743 | PPARγ agonist 2 | ||
PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ. It exhibits significant potential for utilization in metabolic disease research [1]. | |||
T61417 | PPARγ agonist 7 | ||
PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal s... | |||
T61465 | PPARγ agonist 3 | ||
PPARγ agonist 3, also known as Compound 18a, is a potent and selective agonist of PPARγ. This compound does not exhibit cytotoxicity towards both non-resistant and resistant cells. Notably, PPARγ agonist 3 demonstrates a... | |||
T75690 | Wistin | ||
Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] . | |||
T22154 | SR 2595 | ||
SR2595 is an inverse agonist of nuclear receptor PPARγ with an IC 50 of 30 nM [1]. | |||
T75009 | PPARγ/GR modulator 1 | ||
PPARγ/GR Modulator 1, an orally active dual agonist for the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Glucocorticoid Receptor (GR), exhibits Ki values of 3.3 and 33.6 μM, respectively. This compound is... | |||
T37026 | Mesalamine impurity P | ||
Mesalamine impurity P is an impurity of Mesalamine . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1]. [1]. Kyle Dammann, et al.PAK1 modulat... | |||
T60535 | PPARα/γ agonist 1 | ||
PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes. PPARα/γ agonist 1 has EC50 values of 28 nM and 69 nM for PPARα and PPARγ, respe... | |||
T79182 | PPARγ agonist 8 | PPAR | |
PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator response element (PPRE)-luciferase activity with an effective con... | |||
T62968 | PPARα/δ agonist 1 | ||
PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist with EC50 values of 7.0 nM for PPARα and 8.4 nM for PPARδ. PPARα/δ agonist 1 exhibits high selectivity for PPARγ (EC50: 1316.1 nM). agonist 1 has potential for non-a... | |||
T21812 | LT175 | ||
LT175, a dual PPARα/γ ligand, demonstrates potent insulin-sensitizing effects while exhibiting reduced adipogenic properties. This compound is an orally active partial agonist targeting PPARγ, with EC50 values of 0.22 μm... | |||
T83882 | XY-4 | ||
XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively induces reporter gene expression in RAW 264.7 macrophages h... | |||
T61848 | Rosiglitazone potassium | ||
Rosiglitazone (BRL 49653) potassium is a potent and selective PPARγ agonist (EC 50: 60 nM, Kd: 40 nM), administered orally. It also serves as an activator of TRPC5 (EC 50: 30 μM) and an inhibitor of TRPM3. This compound,... | |||
T73842 | Leriglitazone hydrochloride | ||
Leriglitazone (Hydroxypioglitazone) hydrochloride, a pioglitazone metabolite, acts as a PPARγ agonist, effectively stabilizing the PPARγ activation function-2 (AF-2) co-activator binding surface to enhance co-activator b... | |||
T35800 | MD001 | ||
MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. ... | |||
T64011 | GSK1820795A | ||
GSK1820795A, a telmisartan analog, functions as a selective antagonist of hGPR132a, inhibiting the activation of yeast cells that express hGPR132a by N-acylamides [1]. Additionally, it acts as an angiotensin II antagonis... |